After its incorporation, Walpole had a role in the events leading up to the American Revolutionary War. The citizens agreed that the taxes imposed by the British government were unfair. They sent a representative, Joshua Clapp, to the state meetings at Faneuil Hall in Boston. These meetings were to discuss how Massachusetts was going to keep its residents safe and peaceful during the events of the American Revolutionary War. In 1775, Walpole sent 157 men to the Battle of Lexington and Concord. These men were led by Captain Seth Bullard. In December 1777, a British fleet of ships came into Narragansett Bay and anchored in Newport Harbor in Rhode Island. Walpole sent two groups of minutemen, consisting of 65 men in total, to help with the situation. These men were led by Joshua Clapp, and Oliver Clapp. They stayed in Rhode Island to defend the port for three weeks.

Walpole began to grow after the Revolutionary War. By 1860, the town had 1,935 residents. Starting around this time, several mills began to be built, largely on the Neponset River in order to harness the power of falls. Over the years, these mills grew and mainly manufactured products such as cotton, lumber, and paper in its many mills. The most notable of these was the Bird Company, which comprised a large complex on the river in East Walpole. After the company ceased operations at the site in 1980, most of the buildings were razed over the years; a housing development now occupies a large portion of the old mill site and only a few remnants of the area’s former use are still evident. The Neponset River was also used for transport between the close towns of Sharon, Foxborough and Medfield. It was also used as a water supply and for water power. The Norfolk County railroad also connected the town. It was also part of a railroad network that connected Walpole to Boston and New York City. Many churches were formed in Walpole at this time, including Trinitarian, Unitarian and Methodist ones:[8] Union Congregational Church est. 1877, etc.